Bina K. Singh on Muck Rack

Bina K. Singh

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Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications

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By Selma Dahmane, Erin E Schexnaydre, Jianguo Zhang, Bina K. Singh, Ebba Rosendal, Nunya Chotiwan, Kiran Sharma, Emma Nilsson, Marie Peters, Wai-Lok Yau, Sebastian Rönfeldt, Richard Lundmark, Benjamin A. Barad, Danielle A. Grotjahn, Susanne Liese, Andreas Carlson, Anna K. Överby, Lars-Anders Carlson
| Nature Verified
Abstract Flaviviruses replicate their genomes in replication organelles (ROs) formed as bud-like invaginations on the endoplasmic reticulum membrane, which also functions as the site for virion assembly. While this localization is well established, it is not known to what extent viral membrane remodeling, genome replication, virion assembly, and maturation are coordinated. Here, we image tick-borne flavivirus replication in human cells using cryo-electron tomography.
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