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Kiran Sharma

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Articles

STING is a key driver of Japanese encephalitis virus induced inflammatory response

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By Simran Chhabra, dhruvin patel, Kiran Sharma, Vishal Sah, Santosh Chauhan, Manjula Kalia, Krishnan H. Harshan
| Nature Verified
Abstract Interferon (IFN) and inflammation are the key early defence mechanisms that combat pathogen infection. The cytosolic DNA sensor cGAS activates immune signaling via the stimulator of interferon genes (STING) protein. Emerging evidence suggests crosstalk between innate immune DNA and RNA sensing, implicating a role of STING protein in RNA virus infection. This study characterizes STING in the context of Japanese encephalitis virus (JEV), an RNA virus of the flaviviridae family.
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Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications

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By Selma Dahmane, Erin E Schexnaydre, Jianguo Zhang, Bina K. Singh, Ebba Rosendal, Nunya Chotiwan, Kiran Sharma, Emma Nilsson, Marie Peters, Wai-Lok Yau, Sebastian Rönfeldt, Richard Lundmark, Benjamin A. Barad, Danielle A. Grotjahn, Susanne Liese, Andreas Carlson, Anna K. Överby, Lars-Anders Carlson
| Nature Verified
Abstract Flaviviruses replicate their genomes in replication organelles (ROs) formed as bud-like invaginations on the endoplasmic reticulum membrane, which also functions as the site for virion assembly. While this localization is well established, it is not known to what extent viral membrane remodeling, genome replication, virion assembly, and maturation are coordinated. Here, we image tick-borne flavivirus replication in human cells using cryo-electron tomography.
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Automated Classification of Research Papers Toward Sustainable Development Goals: A Boolean Query-Based Computational Framework

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By Kiran Sharma
| arxiv.org
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