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Bingcong Xiong on Muck Rack

Bingcong Xiong

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Catalytic asymmetric synthesis of meta benzene isosteres - Nature

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By Mingkai Zhang, Matthew Chapman, Bhagyesh R. Sarode, James Chen, Eranthie Weerapana, Bingcong Xiong
| Nature Verified
Abstract Although aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug1. Nonoptimal potency, metabolic stability, solubility and lipophilicity in pharmaceutical compounds can be improved by replacing aromatic rings with non-aromatic isosteric motifs2.
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