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Matthew Chapman on Muck Rack

Matthew Chapman

South Australia
As seen in: LinkedIn, MSN UK, Nature, The Guardian, The Telegraph, Salon, Yahoo Sports Canada, RawStory, Daily Nation, AlterNet and
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Articles

Catalytic asymmetric synthesis of meta benzene isosteres - Nature

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By Mingkai Zhang, Matthew Chapman, Bhagyesh R. Sarode, James Chen, Eranthie Weerapana, Bingcong Xiong
| Nature Verified
Abstract Although aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug1. Nonoptimal potency, metabolic stability, solubility and lipophilicity in pharmaceutical compounds can be improved by replacing aromatic rings with non-aromatic isosteric motifs2.
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Digestive exophagy of biofilms by intestinal amoeba and its impact on stress tolerance and cytotoxicity - npj Biofilms and Microbiomes

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By Laura Domínguez-García, Diego Romero, Matthew Chapman, Ilana Kolodkin-Gal, Divya Kolli
| Nature Verified
Abstract The human protozoan parasite Entamoeba histolytica is responsible for amebiasis, a disease endemic to developing countries. E. histolytica trophozoites colonize the large intestine, primarily feeding on bacteria. However, in the gastrointestinal tract, bacterial cells form aggregates or structured communities called biofilms too large for phagocytosis. Remarkably, trophozoites are still able to invade and degrade established biofilms, utilizing a mechanism that mimics digestive exophagy.
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ex-Trump official

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By Matthew Chapman
| MSN UK Verified
A record-setting find Archaeologists have discovered what is thought to be the world's oldest known wooden structure – and it dates back even further than experts thought possible. The new research, undertaken by a team from the University of Liverpool and the University of Aberystwyth, reports on a newly-excavated arrangement of logs at the archaeological site of Kalambo Falls in Zambia, which, at at least 476,000 years old, predates even the evolution of our own species, Homo sapiens.
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