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ArticleVolume 86, Issue 4p585-603.e5 Affiliations & Notes 1State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China 2Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai 200434, China 3Cancer Center, Tongji University School of Medicine, Shanghai 200331, China 4Department of...
Abstract The Warburg effect leads to increased lactate production and promotes cancer progression but the underlying mechanisms remain unclear. Here, we found that lactate activates the MAPK pathway through ERK lactylation, which promotes cancer progression. We identified GCN5 as the lactyltransferase responsible for ERK lactylation.
Keywords lactylation Warburg effect XLF cell-penetrating peptide chemoresistance non-homologous end-joining repair Get full text access Log in, subscribe or purchase for full access. References 1. Vamvakas, S. ∙ Vock, E.H. ∙ Lutz, W.K. On the role of DNA double-strand breaks in toxicity and carcinogenesis Crit. Rev. Toxicol. 1997; 27:155-174 2. Khanna, K.K. ∙ Jackson, S.P. DNA double-strand breaks: signaling, repair and the cancer connection Nat. Genet. 2001; 27:247-254 3. Jeggo, P.A. ∙ Löbrich, M.
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