Bingzi Zhu

1 Introduction Colon cancer (CC) ranks as the third most common malignancy and the second leading cause of cancer-related death worldwide [1, 2]. Currently, surgical resection followed by postoperative chemotherapy is the primary approach for managing CC, with a 5-year survival rate of approximately 60% [1, 3, 4]. Despite significant progress in the field of CC research, the development of new therapeutic strategies is urgently needed.

Back to Journals » ImmunoTargets and Therapy » Volume 15 Authors Bai B , Cui Y, Zhong X, Zhu B, Meng Z , Chen L, Di L, Huang L, Wang J, Jin Z, Lu X, Zhou B Received 17 September 2025 Accepted for publication 13 January 2026 Published 6 February 2026 Volume 2026:15 Pages 1—29 DOI https://doi.org/10.2147/ITT.S563779 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Michael Shurin Binglong Bai,1,* Yuekai...

eLife Assessment This fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. After major revisions, the evidence supporting the conclusions is solid. However, some new experiments are needed to draw more robust conclusions regarding the ferroptosis-associated studies.