Yin Jin

eLife Assessment This fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. After major revisions, the evidence supporting the conclusions is solid. However, some new experiments are needed to draw more robust conclusions regarding the ferroptosis-associated studies.

Introduction Pruritus is a sensation that provokes the desire to scratch (2019European S2k Guideline), which remains one of the most agonizing symptoms for affected patients and a clinical challenge for physicians (Weisshaar et al., 2019). Pruritus may be a result of dermatological diseases or systemic diseases (Satoh et al., 2021). The onset of pruritus with underlying dermatological disease usually coincides with the onset of typical skin lesions (Ständer et al., 2015).