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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Perceptual decisions arise after considering the available sensory evidence [ 1 ]. When sensory information is unreliable, a good strategy is to rely on previous experience in similar situations to guide decisions [ 2–6 ]. It is well known that patients with Parkinson’s disease (PD) are impaired at value-based decision-making [ 7–11 ]. How patients combine past experience and sensory information to make perceptual decisions is unknown.
Importance Genetic factors contribute to risk for bipolar disorder (BP), but its pathogenesis remains poorly understood. A focus on measuring multisystem quantitative traits that may be components of BP psychopathology may enable genetic dissection of this complex disorder, and investigation of extended pedigrees from genetically isolated populations may facilitate the detection of specific genetic variants that affect BP as well as its component phenotypes.
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