CORRESPONDENCE 02 December 2025 Two Comment articles on reforms to animal research rightly call for compassion and innovation (T. J. Herron et al. Nature 646, 799–801 (2025); K. C. K. Lloyd Nature 646, 802–803; 2025). But ending animal studies is premature, and other options, known as new approach methodologies or novel alternative methods (NAMs), are not morally pure.