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Birong Shen

As seen in: Nature, Cell Press
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Articles

Targeting mitochondrial dynamics against cancer

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By Yu-Lu Cao, Chao-Pin Yang, Birong Shen, Junjie Hu, Song Gao
| Cell Press Verified
Keywords mitochondrial dynamics TME immunotherapy Get full text access Log in, subscribe or purchase for full access. References 1. Tabara, L.C. ... Molecular mechanisms of mitochondrial dynamics Nat. Rev. Mol. Cell Biol. 2025; 26:123-146 2. Dorn, 2nd, G.W. Evolving concepts of mitochondrial dynamics Annu. Rev. Physiol. 2019; 81:1-17 3. Archer, S.L. Mitochondrial dynamics – mitochondrial fission and fusion in human diseases N. Engl. J. Med. 2013; 369:2236-2251 4. Li, X. ...
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Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction - Nature Chemical Biology

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By Birong Shen, Song Gao, Deling Kong, Xiaojiang Hao, Junjie Hu
| Nature Verified
Abstract Membrane dynamics are important to the integrity and function of mitochondria. Defective mitochondrial fusion underlies the pathogenesis of multiple diseases. The ability to target fusion highlights the potential to fight life-threatening conditions. Here we report a small molecule agonist, S89, that specifically promotes mitochondrial fusion by targeting endogenous MFN1.
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