Bitten Aagard Jensen on Muck Rack

Bitten Aagard Jensen

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Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum - Nature Genetics

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By Samvida Venkatesh, Duncan Palmer, Nikolas Baya, Melody Parker Verified, Mie T Bruun, Christian Erikstrup, Anders Juul, Christina Mikkelsen, Henriette S. Nielsen, Sisse R. Ostrowski, Ole B. Pedersen, Palle Duun Rohde, Erik S. Sørensen, David Westergaard, Asgeir Haraldsson, Hilma Holm, Ingileif Jónsdóttir, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Minna K. Karjalainen, Benjamin Jacobs, Georgios Kalantzis, Nikki Hubers, Margaret Lippincott, Deborah A. Lawlor, Nicholas J Timpson, Mette Nyegaard, Kari Stefansson, Reedik Mägi, Hannele Laivuori, Dorret I. Boomsma, Ravikumar Balasubramanian, Yee-Ming Chan, Triin Laisk, Bitten Aagard Jensen
| Nature Verified
Abstract Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female infertility. We additionally identify up to 269 genetic loci associated with follicle-stimulating hormone, luteinizing hormone, estradiol and testosterone through sex-specific GWAS meta-analyses (n = 6,095–246,862).
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