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Sisse R. Ostrowski

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Articles

Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy

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By Jaakko S. Tyrmi, Juha Karjalainen, Samvida Venkatesh, Clara Benoit-Pilven, Susanna Lemmelä, Søren Brunak, Bitten Aagaard, Mie T Bruun, Christian Erikstrup, Henrik Ullum, Ole B. Pedersen, Karina Banasik, Erik S. Sørensen, Christina Mikkelsen, Michael C Schwinn, Arni Sturluson, Sisse R. Ostrowski, Johannes Kettunen, Henriette Svarre Nielsen, Mette Nyegaard, David Westergaard, Thorunn Rafnar, Patrick Sulem, Kari Stefansson, Priit Palta, Triin Laisk, Taru Tukiainen, Cecilia M Lindgren, Mark Daly, Aki S Havulinna, Hannele Laivuori
| Nature Verified
Abstract Intrahepatic cholestasis of pregnancy, which affects 0.2–2% of pregnancies, is characterized by pruritus, increased aminotransferase activity and elevated serum bile acids. Previous studies have implicated liver-enriched genes in intrahepatic cholestasis of pregnancy.
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Representativeness of the Danish Blood Donor Study relative to the general population: a cross-sectional assessment

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By Dorte Helenius, Liam Quinn Verified, Christina Mikkelsen, Nanna Brøns, Joseph Dowsett, Susan Mikkelsen, Torben Frøstrup Hansen, Bo Markussen, Mie T Bruun, Bitten Aagaard, Thomas Hansen, Klaus Rostgaard, Henrik Hjalgrim, Andrew J. Schork, Thomas Werge, Christian Erikstrup, Erik S. Sørensen, Maria Didriksen, Sisse R. Ostrowski, Jacob Træholt, Lea A. N. Christoffersen, Kathrine A. Kaspersen, Ole B. V. Pedersen, Khoa M. Dinh
| Nature Verified
Abstract Cohorts that are non-representative of their target population pose a critical challenge, limiting generalizability and potentially yielding misleading effect estimates. To this end, we conducted a cross-sectional assessment of the representativeness of the Danish Blood Donor Study (DBDS)—a nationwide cohort of 170,000 individuals recruited during visits to blood donation centers across Denmark—relative to the Danish general population aged 18–74 years.
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Early chest x-ray severity assessed by the MBrixia score is associated with mortality in hospitalized patients with COVID-19 pneumonia - Scientific Reports

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By Christian Jensen, Ramtin Z Marandi, Junia C. Costa, Dennis Zetner, Carsten Niemann, Sisse R. Ostrowski, Joanne Reekie, Anna Kalhauge, Bruno Ledergerber, Jens Lundgren, Marie Helleberg, Birgit Holten, Kasper S. Moestrup
| Nature Verified
Abstract Chest x-ray (CXR) severity scores, such as the MBrixia score, are associated with COVID-19 severity, but most have not been validated after the introduction of antivirals and dexamethasone as standard of care. The MBrixia score’s association with mortality and the interobserver variability among radiologists remain unclear.
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