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Björn Barenius

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Articles

Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cells

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By Ostap Dregval, Yu-Wei Chang, Emil Kriukov, Xin Tian, Xin Zhe Liu, Dana Trompet, Misty Shuo Zhang, Zhong Li, Joana Pereira, Lars Sävendahl, Ralf H. Adams, Inger Gjertsson, Claes Ohlsson, Giovanni Volpe, Andrei S Chagin, Emiliano Gomez Ruiz, Mats Brittberg, Björn Barenius
| Nature Verified
Abstract Human bone marrow mesenchymal stromal/stem cells (BM-MSCs) are widely used in clinical trials and tissue engineering, yet their native microenvironment remains poorly understood. Here we introduce a tissue-clearing protocol, DeepBone, for human bones and integrate it with simultaneous mRNA and protein detection. Using this protocol, we spatially map BM-MSCs relative to key bone microenvironment components, including human blood capillaries, adipocytes, sinusoids and bony trabeculae.
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