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Abstract Background: Distraction osteogenesis (DO) is an effective reconstructive strategy for large bone defects, but its clinical application is constrained by slow regenerate maturation and prolonged consolidation. The cyclic distraction–compression (CDC, accordion technique) has shown promise in enhancing bone formation; however, its underlying mechanotransduction mechanisms remain poorly understood.
Abstract Osteoarthritis (OA) is a common degenerative joint disease with no curative treatments and a poorly understood etiology. Here, we report that defective sulfation, a largely underexplored chemical modification of lipid metabolites, drives pathogenic lipid accumulation in chondrocytes to promote OA.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.