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Author notes Xiaoxiao Zhong and Fengjiao Ding contributed equally to this work. Authors and Affiliations Department of Breast and Thyroid Surgery, Third Xiangya Hospital Affiliated to Central South University, Changsha, 410011, Hunan Province, China Xiaoxiao Zhong, Fengjiao Ding, Liyuan Qian, Wei Wu, Yanguang Wen & Boni Ding Contributions Xiaoxiao Zhong and Fengjiao Ding drafted the manuscript and assisted with the clinical data collection and interpretation.
Highlights • Probiotics prevented chemotherapy-related cognitive impairment in patients. • Probiotics supplement mitigated chemotherapy-induced metabolic abnormalities. • p-Mentha-1,8-dien-7-ol(i.p.) alleviated CRCI-related brain impairment in rats. Abstract Background Chemotherapy-related cognitive impairment (CRCI) is highly prevalent in patients with cancer and is associated with poor outcomes and quality of life. To date, the management of CRCI remains a clinical challenge.
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