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Boon Haow Chua on Muck Rack

Boon Haow Chua

As seen in: BioRxiv, Genome Research
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Articles

The TARZN complex binds de novo enhancer mutations and promotes oncogenic expression in T-ALL

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By Nurkaiyisah Zaal Anuar, Boon Haow Chua, Joana Costa, Chai Yeen Goh
| BioRxiv
Abstract TAL1 is overexpressed in 40-60% of T-cell acute lymphoblastic leukemia (T-ALL) cases and forms an oncogenic core regulatory circuit (CRC) with other transcription factors such as LMO1, LMO2 and GATA3. In 5% of T-ALL cases an insertion of a consensus GT dinucleotide (MuTE) is observed upstream of the TAL1 gene, driving TAL1 overexpression.
Open in Who Shared Issue with article?

E4F1 and ZNF148 are transcriptional activators of the -57A>C and wild-type TERT promoter

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By Nurkaiyisah Zaal Anuar, Cecilia Domrane, Anna Wittek, Boon Haow Chua
| Genome Research
1,5 1 Cancer Science Institute of Singapore; 2 Universite Paris Cite; 3 Oklahoma State University; 4 IMB Mainz ↵* Corresponding author; email: dennis.kappei{at}nus.edu.sg Received January 20, 2023. Accepted October 23, 2023. This manuscript is Open Access. This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International license), as described at http://creativecommons.org/licenses/by/4.0/.
Open in Who Shared Issue with article?

E4F1 and ZNF148 are transcriptional activators of the -57A>C and wild-type TERT promoter

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By Boon Haow Chua, Nurkaiyisah Zaal Anuar, Cecilia Domrane, Anna Wittek
| Genome Research
E4F1 and ZNF148 are transcriptional activators of the -57A>C and wild-type TERT promoter
Open in Who Shared Issue with article?
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