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Articles by Boxin Chen
MUC13 promotes cisplatin resistance in intrahepatic cholangiocarcinoma through regulation by histone H3K18 lactylation
Abstract Cisplatin resistance remains a major clinical challenge in intrahepatic cholangiocarcinoma (iCCA); however, its underlying mechanisms are poorly understood. Building on our previous study that identified Mucin 13 (MUC13) as an oncogenic driver, we aimed to investigate its contribution to cisplatin resistance.
Histone lactylation-driven IGF2BP3 promotes intrahepatic cholangiocarcinoma progression via SPP1/CD44-dependent macrophage polarization
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Abstract The tumor microenvironment is a critical regulator of cancer progression. Histone lactylation, a novel post-translational modification, has emerged as a key player in various tumors and is closely linked to macrophage polarization within the immune tumor microenvironment. Here, we delineated the signaling axis through which histone lactylation, specifically H3K18la, orchestrates crosstalk between intrahepatic cholangiocarcinoma cells and the tumor microenvironment (TME).
By Zhijie Yin, Jia Sun, Yinfan Wang, Boxin Chen, Chen Jia, Zhen Cui, Ze Wang, Wenjun Chen, Zejun Luo, Ming Yang Verified, Ming Zhao, Peng Xiao, Qingfu Lang, Tiemin Pei
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Nature
Verified
Self‐Assembled Carrier‐Free Nanomedicines Potentiate Chemo‐Photothermal Immunotherapy by Overcoming Prostaglandin E2‐Mediated Immunosuppression
1 Introduction Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, represents approximately 15% of all breast cancer cases [1]. This subtype is characterized by aggressive clinical behavior, a high risk of early recurrence, and a paucity of targeted treatment strategies [2].
Machine Learning‐Driven Grayscale Digital Light Processing for Mechanically Robust 3D‐Printed Gradient Materials
1 Introduction Digital light processing (DLP) is a photopolymerization-based 3D printing method recognized for its versatile material selection and rapid, high-resolution capabilities.[1] In DLP, the mechanical tunability of photocurable resins is crucial for optimizing properties to meet specific application demands.[2-5] This tunability is achieved by precisely controlling material compositions and ratios, enabling the development of hydrogels for medical applications and ionic or...
A semi-packed gas chromatographic column with staggered elliptic cylindrical posts arrays
A semi-packed gas chromatographic column with staggered elliptic cylindrical posts arrays The semi-packed gas chromatographic column has the advantages of high specific surface area and low column pressure. This paper reports that the stagnation regions formed in the adjacent posts along the channel of the semi-packed columns can decrease the area and height of chromatographic peaks, which makes it difficult to detect low-concentration mixed gases.
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