Zhijie Yin

Abstract The tumor microenvironment is a critical regulator of cancer progression. Histone lactylation, a novel post-translational modification, has emerged as a key player in various tumors and is closely linked to macrophage polarization within the immune tumor microenvironment. Here, we delineated the signaling axis through which histone lactylation, specifically H3K18la, orchestrates crosstalk between intrahepatic cholangiocarcinoma cells and the tumor microenvironment (TME).

Echinacea purpurea hydroxycinnamoyl-CoA:tartaric acid hydroxycinnamoyl transferase (EpHTT) is a cytosolic BAHD acyltransferase that catalyzes the transfer of caffeoyl groups to tartaric acid, a key step in chicoric acid biosynthesis. Understanding the structure of EpHTT is essential to elucidate the molecular basis of substrate recognition and catalytic specificity.

The surface protein P113 serves as a membrane-anchored protein that tethers the Plasmodium falciparum RH5 complex, including its associated partners CyRPA and RIPR, to the parasite surface. This anchoring mechanism ensures the proper localization and stabilization of RH5, facilitating its critical interaction with the host erythrocyte receptor basigin during erythrocyte invasion.