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ArticleOnline now102832Open access Affiliations & Notes 1Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA 2Department of Electrical and Computer Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA 3Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA 4Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA...
Abstract Neuronal firing sequences are thought to be the building blocks of information and broadcasting within the brain. Yet, it remains unclear when these sequences emerge during neurodevelopment. Here we demonstrate that structured firing sequences appear in spontaneous activity of human and murine brain organoids, both unguided and forebrain identity directed, as well as ex vivo neonatal murine cortical slices.
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