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Bradley Harris

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Articles

Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn’s disease pathogenesis

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By Monika Krzak, Tobi Alegbe, Gareth-Rhys Jones, Mennatallah Ghouraba, Michelle Strickland, Bradley Harris, Reem Satti, Kenneth Arestang, Lucia Ramirez-Navarro, Nilanga Nishad, Marcus Tutert, Matiss Ozols, Guillaume Noell, Steven Leonard, Moritz J. Przybilla, Ciro Ramirez Suastegui, Eleonora Khabirova, Tong Deng, Hanna Najgebauer, Velislava N. Petrova, Carla Jones, Noor Wana, May Xueqi Hu, Jason Skelton, Jasmin Ostermayer, Yong Gu, Wendy Garri, Biljana Brezina, Daniele Corridoni, Miles Parkes, Vivek N. Iyer, Cristina Martin Verified, Rebecca McIntyre, Tim Raine, Carl A. Anderson
| Nature Verified
Abstract Crohn’s disease (CD) is a chronic inflammatory bowel disease exhibiting substantial heterogeneity in clinical presentation and response to therapy. To explore its molecular basis, we developed IBDverse, a large single-cell RNA sequencing (scRNA-seq) dataset of terminal ileal biopsies, profiling over 1.1 million cells from 111 patients with CD and 232 healthy controls.
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Cell-type-resolved genetic variation shapes inflammatory bowel disease risk

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By Tobi Alegbe, Bradley Harris, Laura Fachal, Lucia Ramirez-Navarro, Monika Krzak, Michelle Strickland, Matiss Ozols, Céleste E Cohen, Saniya Khullar, Eleonora Khabirova, Nikolaos Panousis, David Ochoa Verified, Jason Skelton, Jasmin Ostermayer, Yong Gu, Claire Dawson, Tina Thompson, Kenneth Arestang, Nilanga Nishad, Biljana Brezina, Steven Leonard, Vivek N. Iyer, Miles Parkes, Chris Wallace, Rebecca McIntyre, Cristina Martin Verified, Gareth-Rhys Jones, Tim Raine, Carl A. Anderson, Marcus Tutert, Mennatallah Ghouraba, Noor Wana, May Xueqi Hu, Wendy Garri
| Nature Verified
Abstract Most genetic variants associated with complex diseases lie in non-coding regions1, complicating efforts to identify effector genes and relevant cell types. Here we map cis-expression quantitative trait loci (eQTLs) across 2.2 million single cells using intestinal biopsies and blood from 421 individuals, including 125 with inflammatory bowel disease (IBD).
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