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Brian Barnstein on Muck Rack

Brian Barnstein

As seen in: The Journal of Immunology
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Articles

The role of Pdia3-dependent 1α,25-dihydroxy vitamin D3 signaling on IgE-mediated mast cell activation

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By Bianca Baker, Nicholas Clark, Barbara D. Boyan, Zvi Schwartz, Brian Barnstein
| The Journal of Immunology Verified
Active 1,25(OH)2 Vitamin D3 (1,25D3) is most commonly known for its role in the regulation of bone metabolism. However, research has now indicated it is a potent immune regulator beyond its calcemic effects. Vitamin D deficiency has been implicated in the pathogenesis of allergic diseases including asthma and atopic dermatitis. 1,25D3 is known to signal through the canonical Vitamin D receptor (VDR) facilitating its anti-inflammatory properties and regulating over 100 genes.
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