Brian Bartek

Abstract Introduction Sepsis, a syndrome of life-threatening organ dysfunction caused by infection (1), remains a major global health concern, accounting for an estimated 11 million deaths annually, or 20% of all deaths worldwide (2). Despite decades of research and numerous randomized clinical trials (3), mortality rates remain consistently above 20% (2, 4, 5). Due to its broad clinical definition (6), sepsis is a highly heterogeneous clinical diagnosis.

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