Brian Cooley
- Communications Trainer, A.P. Giannini Foundation
- Principal, Cooley Insights
San Francisco, United States
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Principal, Cooley Insights
Articles by Brian Cooley
What it means to be a pet-inclusive community
It’s no secret that pets are an integral part of a healthy and happy community. Pets get us out of the house, encourage relationships with new people and foster stronger neighborhood bonds. A new program called Pet Inclusive Novato has just launched and we hope more cities in Marin add their own Pet Inclusive programs. Pet Inclusive Novato encourages and celebrates pet-inclusive practices in Novato housing, restaurants, hotels, retail stores and workplaces.
Nick Hern Books | About Andy Barker
Andy Barker is a certified performance coach, trainer and author with diverse work experience in the arts and corporate senior management. He has worked in the music industry, the film industry, the world of theatre, videogames, and learning and development. Highlights include working with Jim Henson's Muppets and with Andrew Lloyd Webber's numerous West End productions.
Navigating The 83(b) Election: Risks And Rewards Of Early Taxation
Internal Revenue Code § 83 governs the taxation of property (e.g., stock, restricted stock units, or stock options) transferred in connection with the performance of services.
Sunriver Realty Unveils New Look & Vision for a New Era
(Sunriver Realty Team | Photo courtesy of Sunriver Realty) Sunriver Realty, the leading real estate brokerage in Sunriver, Oregon with a rich history in the community, is ushering in a new era of innovation and a hyper-focus on serving the local real estate marketplace. With an unparalleled understanding of Sunriver’s distinctive charm and allure, the brokerage is redefining the region’s real estate experience for buyers, sellers and vacation home renters.
Phantom Stock 101: A Primer On Invisible Equity - - United States
Phantom stock plans are a deferred compensation tool companies can use to attract, motivate, and retain talented employees. These plans (also known by many other names, i.e., shadow stock plans, phantom equity plans, synthetic equity programs, etc.) offer employees some of the benefits of stock ownership without transferring company equity.
Is AI the Remedy to All Those ‘Smart’ Tech Letdowns?
By Brian Cooley, Editor at large, CNET Smart homes, smartwatches and smart TVs are not that smart. They offer remote control, customization, crude pattern matching and some sensing, but are a far cry from being intelligent. If they were, your TV’s streaming recommendations would actually interest you, your watch would reduce notification fatigue, not add to it, and your home would realize that your utterances, presence and gestures are all subtle commands if devices would just notice them.
Recapture the Joy
My eight-grade fingers trembled as I typed “RUN” and hit RETURN. The whole class was gathered around the tiny CRT that served as the monitor for one of the class Commodore 64 computers. It was my third attempt at running the text-based baseball simulator that I had been working on for weeks as a class project. Finally, the debugging of the spaghetti logic contained in the hundreds of lines of IF and GOTO statements had paid off. The program was running and running as designed.
What it means to be a ‘Better City for Pets’
This month, Novato was recognized as a “Better City for Pets,” one of just seven Bay Area cities that’ve been designated as the best for people who live, play and work with their pets. This recognition lays out next steps for Novato to be an even more pet-inclusive city and a model for all of Marin. According to the American Society for the Prevention of Cruelty to Animals, “Pet-friendly cities are more economically vibrant and have higher qualities of life.
Sorrento Announces Phase 3 Trial Met Primary Endpoint and Original
In the phase 3 trial, a randomized double blind and placebo-controlled pivotal study, 1,212 mild or moderate COVID-19 patients were enrolled and treated with OVYDSO™ (Olgotrelvir) or placebo. The primary endpoint was time to sustained recovery of 11 COVID-19 related symptoms and the key secondary endpoint was the viral RNA copy load reduction.
Sorrento Announces Positive Phase IIa Study Results of Original
Abivertinib is a novel Bruton’s tyrosine kinase (BTK) inhibitor that irreversibly targets BTK. BTK inhibitors are a large category in cancer treatment, with multiple indications and generating over $10.6 billion per year revenue in 2022.
Sorrento Announces the Full Enrollment of the Pivotal Phase Original
The Phase 3 study of Ovydso was initiated in China in February 2023 and enrolled and dosed 1,200 COVID-19 patients (1:1, active:placebo) at 25 sites in China. During the trial, Ovydso has maintained an excellent safety profile with no Grade 3 toxicities reported. We anticipate top line data in the third quarter of this year.
How Electric Cars Work – CNET [CNET]
Before you buy your first EV, here’s a simple explanation of what’s under the hood. View Article on CNET Before you buy your first EV, here’s a simple explanation of what’s under the hood. There’s plenty of hype around EVs, but has anyone explained to you how they work? Here are the basics for people who just want to know what they’re buying without geeking out.
The Total Cost of Owning an Electric Car Is Its Secret Weapon – CNET [CNET]
Advantages beyond sticker price and fuel savings complete the story that will tip EVs into ubiquity. View Article on CNET Advantages beyond sticker price and fuel savings complete the story that will tip EVs into ubiquity. If you’re waiting for longer range, faster charging and lower sticker prices before buying an EV, you might already be missing the boat: An electric car’s total cost of ownership is challenging that of combustion engine cars and may soon make an EV the only logical car to buy.
Sorrento Therapeutics, Inc. announces a $4.6 Million U.S. Original
SAN DIEGO, June 13, 2023 (GLOBE NEWSWIRE) -- Sorrento Therapeutics, Inc. (OTC: SRNEQ, "Sorrento") today announces it has been awarded a $4.6 million contract from the National Institute of Allergy and Infectious Diseases, a part of the National Institutes of Health (NIH) for the development of in vitro diagnostics for biodefense, antimicrobial resistant infections and emerging infectious diseases.
Shanghai Escugen Biotechnology Co., Ltd., a partner of Original
CHICAGO, June 05, 2023 (GLOBE NEWSWIRE) -- Shanghai Escugen Biotechnology Co., Ltd. (“Escugen”), a partner of Levena (Suzhou) Biopharma Co., Ltd. (“Levena”), a wholly owned subsidiary of Sorrento Therapeutics, Inc.
Sorrento Releases Positive Results from a Phase 1b Study in Original
Topline safety, antiviral effectiveness and pharmacokinetic (PK) data from a Phase 1b Study in China are released from the single ascending dose (SAD) portion of the study with the doses from 300 mg to 2,000 mg in 32 healthy volunteers and the multiple ascending dose (MAD) portion of the study in 46 COVID-19 patients with 300 mg BID, 600 mg BID and 800 mg BID daily dosing for 7.5 days.
Sorrento to Host Webcast to Discuss Newly Presented Original
ATLANTA and SAN DIEGO, Nov. 13, 2022 (GLOBE NEWSWIRE) -- Sofusa®, a wholly-owned division of Sorrento Therapeutics (Nasdaq: SRNE, “Sorrento”), today announced that it will host a virtual Key Opinion Leader (KOL) panel discussion titled “Empowering the Lymphatics: Unleashing the Potential of Biologics that Target the Immune System” to be held on Thursday, November 17, 2022 at 11:30 AM EST.
Scilex, a Sorrento Company, Announces Initiation of a Phase Original
Dosing of the first subject in a Phase 2, randomized, double-blind, placebo-controlled, parallel group, multicenter study to evaluate the safety and efficacy of SP-103 (lidocaine topical system) 5.4% in subjects with moderate to severe acute lower back pain (LBP). The trial will enroll 80 patients with acute lower back pain.
Sorrento Therapeutics, Inc. Appoints Former Roche Executive Original
SAN DIEGO, May 18, 2022 (GLOBE NEWSWIRE) -- Sorrento Therapeutics, Inc (Nasdaq: SRNE, “Sorrento”), a commercial and clinical-stage biopharmaceutical company dedicated to developing and commercializing targeted therapies and diagnostics, announced today the appointment of former Roche Laboratories executive, Tammy Reilly, to Sorrento’s board of directors.
Sorrento’s License Partner, Lee’s Pharm, Announces Full Original
Socazolimab (anti-PD-L1 monoclonal antibody) was discovered by Sorrento from its fully human antibody G-MABTM library and licensed by China Oncology Focus Limited (“COF”), a Lee’s Pharm subsidiary, for the Great China Territories.
Sorrento Announces FDA Authorization to Proceed With Phase Original
FDA granted IND clearance for Abivertinib (Fujovee™) for the Phase 2 MAVERICK study to be conducted in participants with metastatic castrate resistant prostate cancer (mCRPC) at multiple centers in the United States.
Scilex Holding Company, a Sorrento Company, and Vickers Original
PALO ALTO, Calif. and NEW YORK, May 16, 2022 (GLOBE NEWSWIRE) -- Scilex Holding Company (“Scilex”), a Sorrento Company (nearly 100% or over 99.9% majority-owned subsidiary of Sorrento Therapeutics, Inc.) (Nasdaq: SRNE, “Sorrento”) and Vickers Vantage Corp.
The Real Costs of Electric Car Ownership
By Brian Cooley, CNET At a time when it costs up to $100 to fill a gas tank, but as little as $10 to charge an electric car, buying an EV may seem like an obvious choice. But EV economics are complicated and you need to be savvy about a lot of unfamiliar factors before you can stick it to the oil companies. Buying a new car To drive an EV you have to buy an EV, an often pricey proposition. Even after you sell or trade your current, conventional car you could easily be in the hole $10,000 or more.
Scilex, a Sorrento Company, Highlights Safety Data From Original
SP-104 is a novel, proprietary, fixed dose, delayed burst release of low dose naltrexone hydrochloride, 4.5 mg, for treatment of fibromyalgia (FM).
Scilex, a Sorrento Company, Announces Pivotal Phase 3 Original
SP-102 (SEMDEXATM) is the first non-opioid novel injectable corticosteroid gel formulation product in development for the treatment of lumbar radicular pain, and it contains no preservatives, surfactants, solvents, or particulates. The study met its primary endpoint with a highly statistically significant reduction in average daily leg pain in patients receiving SEMDEXATM compared to placebo (p<0.001).
Levena Biopharma, A Sorrento Company, Announces Positive Original
A166 is a third-generation antibody drug conjugate (ADC) against HER2-positive breast cancer with Levena Biopharma’s proprietary tubulin inhibitor Duo-5 toxin, cleavable linker and site-specific K-Lock™ conjugation chemistry. A166 has demonstrated promising antitumor activity with clinically meaningful responses in heavily pretreated subjects with HER2-positive breast cancer.
Sorrento Announces Full Enrollment of Phase I Study of Original
The Phase I safety and pharmacokinetic study in 24 healthy volunteers has completed enrollment. The study is still blinded, but only 5 minor adverse events requiring no treatment have been reported in the entire study to date, similar to the safety profile observed in Sorrento’s COVIDROPSTM (STI-2099) product candidate in Phase I and two Phase II studies (US and UK).
Scilex Holding Company, a majority-owned subsidiary of Original
PALO ALTO, Calif., April 27, 2022 (GLOBE NEWSWIRE) -- Scilex Holding Company (“Scilex”), a nearly 100% (or over 99.9%) majority-owned subsidiary of Sorrento Therapeutics, Inc.
Sorrento Announces FDA Authorization to Proceed with Phase Original
April 25, 2022 09:30 ET | Source: Sorrento Therapeutics, Inc. Sorrento Therapeutics, Inc. San Diego, California, UNITED STATES FDA granted IND clearance today for STI-9167 (Intravenous COVISHIELD™) for a Phase 1 safety and pharmacokinetic study in healthy volunteers. Initial trials are expected to be followed by a multinational Phase 2/3 trial in both mild and moderate COVID-19 patients.
Dr. Henry Ji, Sorrento Therapeutics’ Chairman and CEO and Original
SAN DIEGO and PALO ALTO, Calif., April 25, 2022 (GLOBE NEWSWIRE) -- Sorrento Therapeutics, Inc. (NASDAQ: SRNE, “Sorrento”) today announced that Dr. Henry Ji, Chairman and CEO of Sorrento and Executive Chairman of Scilex Holding Company (“Scilex”), will participate in the B. Riley Virtual Neuro & Opthalmology Healthcare Conference at 10:00AM ET on April 27, 2022. Live audio of the event can be accessed by visiting the “Events” page of Sorrento’s website at sorrentotherapeutics.com.
Sorrento Reports FDA Clearance for the Commencement of a Original
March 31, 2022 09:00 ET | Source: Sorrento Therapeutics, Inc. Sorrento Therapeutics, Inc. San Diego, California, UNITED STATES Abivertinib is a novel oral small molecule tyrosine kinase inhibitor that selectively targets both mutant forms of the epidermal growth factor receptor (EGFR) as well as Bruton's tyrosine kinase (BTK) and potentially can reduce cytokine storm associated with acute respiratory distress syndrome (ARDS) in severe hospitalized COVID-19 patients.
Here's why windshield repair downright sucks with modern technology
A lot of modern technology is a real saving grace to make our lives easier. But, sometimes, it can make once simplistic acts a real pain. Windshield repair falls in the latter category. The days of a windshield serving as a piece of glass are long gone, folks. Instead, technology that works with modern cars makes it so much more than something to keep precipitation out. And these repairs are become far more costly, too.
Need to change a tire? Follow this simple guide
Don't feel like you need to call AAA if you have a flat tire. If you've got a car with a flat tire, just stay right here and we'll show you how to change your own tire with ease. We promise it's simple enough. © Provided by Roadshow Doesn't exactly inspire confidence, does it? But the jack in your car's trunk or storage compartment is an easy tool to change your flat and get you back on your way quickly. eBay Here's a short video explaining the simplest and safest way to change a flat tire.
Model‐dependent contributions of FXII and FXI to venous thrombosis in mice
Abstract Background The intrinsic pathway factors (F) XII and FXI have been shown to contribute to thrombosis in animal models. We assessed the role of FXII and FXI in venous thrombosis in three distinct mouse models. Methods Venous thrombosis was assessed in mice genetically deficient for either FXII or FXI. Three models were used: the inferior vena cava (IVC) stasis, IVC stenosis, and femoral vein electrolytic injury models.
Forget overpopulation, many countries are running out of young people. Now what?
"Population problem" has always been synonymous with overpopulation, but the trendlines in many societies suggest the problem will soon be too few people, thanks to access to birth control, greater availability of education, increased affluence and women entering the workforce. Now what? "It's important to think about population decline not as necessarily good or bad.
Programs help renters and pets stay together
Seventy-two percent of renters have pets, according to the Humane Society of the United States, yet the inability to find pet-friendly rental housing is a leading reason why animals are relinquished to shelters. At Marin Humane, it’s the most common reason given when someone surrenders a pet to us. We’ve seen many pet guardians say a sad goodbye to their pets at our Novato campus when they run out of time or options to find pet-friendly rental housing in Marin County.
Porsche developing gasoline as clean as an electric car
Brian Cooley 4 hrs ago While the world is in convulsions over how many cars will be electrified, some companies are working on a cleaner gasoline instead. Porsche eFuel is an example that's getting a lot of attention. © Porsche It may sound absurd to pursue a new kind of fuel to burn in the era of electrification, but Porsche is looking at how combustion can be made roughly as clean as the entire process of electric car transportation, including.
Universal basic income would pay a lot of people, but that's just half the story
Brian Cooley 16 mins ago When Universal Basic Income is mentioned, talk usually turns to who would receive a checks and in what amount. But the most interesting angle might be who benefits from those recipients spending that money, and what they might have to give up to get it. Viewed those ways, UBI could be seen as a vast permanent stimulus plan for American business or a public benefits shell game. Now what?
What will happen to gas stations in the future?
The future of gas stations probably comes down to one big concept: Migrating back to when they were called "service stations" and reimagining what that means on 150,000 pieces of prime US real estate today. © CNET The National Association of Convenience Stores says 120,000 so-called "C stores" also sell fuel, accounting for the majority of gas stations. While the gasoline brings you in, the C store makes the business really work.
How to get your cracked windshield repaired in the age of the high-tech car
A car's windshield was seldom considered high tech and replacing one was not much different from replacing a broken window pane in your house. Things have changed and late-model car windshield repair is often an excursion into sensors, cameras and calibration that can multiply the cost and complexity of . Here's what you need to know when you get a windshield replaced today.
Cultured meat is here and at your door
A food entrepreneur might be offended when told their product "tastes like chicken." Not Josh Tetrick, CEO of Eat Just: For him, that's a huge win. Eat Just's cultured chicken has been approved for sale in Singapore under the brand Good Meat, a watershed moment in the commercialization of cultured meat, which is grown from meat cells without an actual animal being slaughtered. "What this does," says Tetrick, "is open a door." © Eat Just Eat Just's cultured chicken bites.
Why today's windshields are getting a lot more expensive to replace
Replacing a damaged windshield used to be so easy: and they come to where your car's parked and replace it while you work or watch TV. But that's changing as car windshields become the home of many complex technologies related to automated driver assistance systems. © Subaru Technologies like Subaru's highly regarded Eyesight camera system are driving collision avoidance deep into the affordable car category.
How to make emergency flasher hazard lights much better
Your car's flashing hazard lights are pretty simple, right? You push a button, they flash; you push the button again and they stop. But that simple system is more nuanced than you might think -- and way overdue for an update. Here's how your emergency hazard flashers might be improved in the near future to keep you safe. © CNET © Provided by Roadshow Red hazard lights of indiscriminate shape are far from the best design for an effective emergency flasher, but that's what we're stuck with on cars.
The worst new car fee is the destination charge
© CNET The destination fee is chunky, but doesn't even get put in bold. After haggling for half a day over the price of a new car, you may forget about the $1,000 or more destination fee that lurks separate from the car's manufacturer's suggested retail price. It's one of the most opaque and frustrating charges you face when buying a new car because it's basically non-negotiable and its cost has soared.
Low-tech car tech you might not know you have
© YourMechanic.com Power window switches in modern cars require you pull up to close the window, for safety. Driver's technology drives a big part of the new car market today, but even the most modest car has a wealth of simple technology that you may not appreciate. Use this list to look around your car and see if there are any handy low-tech features you didn't know about. Extending or double sun visors can block the sun from two directions at once. One-touch express up and down windows.
Artificial intelligence: Are we doing it all wrong?
© Wikimedia The artificial intelligence or "AI" label is slapped on almost anything electronic these days, from "smart" toothbrushes to cancer-curing supercomputers. If you're like me you've become jaded by the AI rubric, realizing we're still a long way from true intelligence in machines. Now what? © Provided by CNET Jeff Hawkins, co-founder of Numenta.
Keep your catalytic converter from being stolen
© CNET A cottage industry of security shields has grown up around the phenomenon of catalytic converter thefts. Thieves are stealing catalytic converters from cars at alarming rates to cash in on the precious metals inside them. Average replacement cost "is getting near a thousand dollars as the cost of the converters just keeps going up," says Don Johnson, proprietor of Johnny Franklin's Mufflers in San Rafael, California.
Choosing the right motor oil for your car is easy
Motor oil is one of those things that's full of brands, boasts and BS. It's actually really easy to get the right motor oil and move on with your life. Here's a synopsis of what you need to know to select the right oil for your car. See the video for the full story and a look behind all those numbers. (By the way if you're looking for a religious discussion of synthetic vs. conventional, you came to the wrong church.
Is an Apple car the next iPod or the next Apple Television?
© Aristomenis Tsirbas Designer Aristomenis Tsirbas won a contest to imagine the Apple Car back in 2015, but the company has yet to produce one. Where does a car fit in Apple's plans? The iPod represents one possible comparison: It was a pivotal product that moved Apple from being just a computer company, and it set the table for the iPhone. Or it could be like the Apple Television, which represented an obvious entry point but into an otherwise unattractive market -- but it never happened.
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