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Brian Smith

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Pottsville
As seen in: Republican Herald, Facebook, Nature, The Independent (UK), Wiley Online Library, Bandcamp Daily, PLOS Biology, Frontiers, PNAS, Taylor & Francis Online, JAMA Oncology and
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Articles

Increased contact transmission of contemporary Human H5N1 compared to Bovine and Mountain Lion H5N1 in a hamster model

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By Reshma Koolaparambil Mukesh, Franziska Kaiser, Jonathan Schulz, Shane Gallogly, Jessica Prado-Smith, Arthur Wickenhagen, Brian Smith Verified, Chad S. Clancy, Carl Shaia, Emmie de Wit, Neeltje van Doremalen, Claude Kwe Yinda, Vincent J. Munster, Kathleen Cordova
| Nature Verified
Abstract The ongoing outbreak of highly pathogenic avian influenza virus (HPAIV) subtype H5N1 in the U.S. poses a significant public health threat. To date, 70 human cases have been confirmed in the United States, including two severe cases and one fatality. While suitable animal models are crucial for predicting the potential pandemic risk of newly emerging pathogens in humans, studies investigating contemporary HPAIV H5N1 transmission dynamics remain limited.
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January 2026 Wills Eye Resident Case Series

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By Turner D. Wibbelsman, Kara Jones, Brian Smith Verified, Martin Calotti
| Review of Ophthalmology Verified
Presentation A 54-year-old male line worker presented to a community hospital after an arc flash from a malfunctioning powerline transformer (estimated 7,200-volt flash). He was a few feet from the transformer and wore recommended personal protective equipment, including industrial UV-tinted protective eyewear. At the outside hospital, he had burns to the face, neck and upper chest, with severe eye pain and mild blurry vision OU.
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PCR vs. Microbial Culture: Is it Time for a Diagnostic Paradigm Shift?

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By Brian Smith Verified, Ravi Patel
| Review of Ophthalmology Verified
When faced with a case of infectious keratitis, the gold standard for the differentiation of causative organisms has been corneal scrapings for smear and laboratory culture for many years. This can be time consuming, in the middle of a busy clinic day and sometimes can yield negative or clinically irrelevant results. In recent years, polymerase chain reaction has become a potential alternative for rapid microbial identification for the causative organism in IK.
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