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Brian Smith on Muck Rack

Brian Smith

Milwaukee
As seen in: LinkedIn, Microsoft Learn Blog, Red Hat, The New York Times, HuffPost, Nature, Wiley Online Library, MDPI, Science Magazine, Cell Press and
Associate Professor of Biochemistry at the Medical College of Wisconsin @medicalcollege. Lab tweets: @briansmithlab
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Articles

Supercharge RHEL troubleshooting with agentic AI: Introducing goose

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By Brian Smith
| Red Hat
AI is rapidly transforming how system administrators and developers interact with their environments. In 2025, we introduced the command line assistant, an optional tool available in Red Hat Enterprise Linux (RHEL) that allows users to ask questions and get natural language troubleshooting guidance right from the terminal.
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Empower your AI tools with new agent skills for Red Hat Enterprise Linux

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By Brian Smith
| Red Hat
AI tools are transforming how system administrators and developers manage their infrastructure,  but when using generic AI assistants to troubleshoot Red Hat Enterprise Linux (RHEL) systems, the advice can sometimes lack distribution-specific context. An AI tool might assume a different Linux environment, suggest commands from other distributions that do not apply to RHEL, or recommend disabling critical security controls to resolve a permissions issue.
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Mitochondria-targeted metformin analogs activate the ER stress-unfolded protein response pathway to drive apoptosis in pancreatic cancer

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By Maria Poimenidou, Donovan Drouillard, Tyler Harris, Elisabeth Solis, Donna McAllister, Robert Keyes, Kazuhiro Aoki, Daisy Sahoo, Balaraman Kalyanaraman, Brian Smith, Michael B. Dwinell, Jordan M. Bobek, Chad Darnell, Mayumi Ishihara-Aoki
| Nature Verified
Abstract Accumulating evidence indicates that evasion of apoptosis and metabolic reprogramming are necessary for pancreatic cancer growth, early invasion, and chemotherapeutic resistance. Building on our prior work, we investigated the anti-tumor potential of a rationally designed mitochondria-targeted variant of the anti-diabetic drug metformin, Mito-Met10, in cell culture models and orthotopic xenografts.
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