Brian Smith on Muck Rack

Brian Smith

Milwaukee
As seen in: LinkedIn, Microsoft Learn Blog, Red Hat, The New York Times, HuffPost, Nature, Wiley Online Library, MDPI, Science Magazine, Cell Press and
Associate Professor of Biochemistry at the Medical College of Wisconsin @medicalcollege. Lab tweets: @briansmithlab
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Articles

Mitochondria-targeted metformin analogs activate the ER stress-unfolded protein response pathway to drive apoptosis in pancreatic cancer

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By Maria Poimenidou, Donovan Drouillard, Tyler Harris, Elisabeth Solis, Donna McAllister, Robert Keyes, Kazuhiro Aoki, Daisy Sahoo, Balaraman Kalyanaraman, Brian Smith, Michael B. Dwinell, Jordan M. Bobek, Chad Darnell, Mayumi Ishihara-Aoki
| Nature
Abstract Accumulating evidence indicates that evasion of apoptosis and metabolic reprogramming are necessary for pancreatic cancer growth, early invasion, and chemotherapeutic resistance. Building on our prior work, we investigated the anti-tumor potential of a rationally designed mitochondria-targeted variant of the anti-diabetic drug metformin, Mito-Met10, in cell culture models and orthotopic xenografts.
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Enzo Zelocchi and the Economics of Building a Screen Career

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By Brian Smith
| Vocal
Building a sustainable career in the entertainment industry requires far more than talent alone. Acting, at its core, is both an art and a business—one where creative ambition must align with economic reality. Enzo Zelocchi’s career offers a compelling case study in how modern actors navigate this balance, combining discipline, branding, and strategic decision-making to create long-term professional value.
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#airlines | Edward Russell | 15 comments

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By Edward Russell, Brian Smith, Noah Downer, Jason Stollman
| LinkedIn
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