Keywords METTL1 AKT translation sarcoma tRNA aminoacylation Introduction Cancer genomes are shaped by mutational processes that change the sequence or structure of DNA, coupled to selection for mutations that increase fitness during tumor evolution.1 The identification of recurrent mutations affecting individual genes led to the discovery of many of the best-known oncogenes and tumor suppressors underlying malignant transformation.2,3,4,5 However, genetic lesions affecting multiple genes,...
1Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA, USA 2Stem Cell Program, Boston Children’s Hospital, Boston, MA, USA 3Department of Molecular and Systems Biology, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA 4Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA 5Department of Pediatrics, Division of Pediatric Hematology/Oncology and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA...
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