Bridget E. Barber
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The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria
Editor’s summary Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Editor’s summary The pyrrolidinamide drug MMV367 has been tested preclinically as an antimalarial. Barber et al.
The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria
Bridget E. Barber, Robin Denhardt-Eriksson, Etienne A. Guirou, Julia Flynn, Nischal Sahai, Indika Leelasena, Susan Mathison, Chris Moller, Ivan Lim, Carla Evangelista, Rebecca Webster, Adam J. Potter, Stacey Llewellyn, Fiona H. Amante, Jeremy Gower, Jenny Peters, David S. Khoury, Vandana Thathy, Sunil K. Narwal, Tomas Yeo, David A. Fidock, Michael W. Marx, Francisco-Javier Gamo, Raman Sharma, Rachel A.
Age is an intrinsic driver of inflammatory responses to malaria - Nature Communications
Abstract Age is a critical factor in immune responses to infection. In malaria, severe disease risk increases with age in non-immune individuals. Malaria severity is in part driven by inflammation, but mechanisms contributing to age-dependent disease risk are incompletely understood. We assessed inflammatory cytokines during malaria in non-immune children and adults, and innate cell responses in vitro to malaria parasites in naive children and adults.
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