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Innate antiviral and immune functions associated with the HIV reservoir decay after anti-PD-1 therapy - Nature Medicine

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By Aarthi Talla, Muhammad Latif, Gabriela Sánchez Verified, Adam Pelletier, Sangeeta Kumari, Viviane Schuch, Khader Ghneim, Ajantha Rhodes, Frank Maldarelli, Robert Yarchoan, Kathryn Lurain, Ramya Ramaswami, Elad Sharon, Bruce Hess, Javier Martinez-Picado, Nicolas Chomont, Sharon Lewin, Steven Deeks, Steven Fling, Thomas Uldrick, Ashish Sharma, Rafick-Pierre Sekaly, Ana B. Enriquez, Saswat Kumar Bal, Leonard D’Amico, Martin A. Cheever
| Nature Verified
Abstract Antiretroviral therapy (ART) suppresses HIV but does not eliminate the latent viral reservoir, which persists in programmed cell death protein 1 (PD-1)-expressing CD4+ T cells. Anti-PD-1 therapies have reduced the HIV reservoir in people living with HIV (PLWH) and cancer; however, the individuals who benefit and the mechanisms driving reservoir reduction remain unclear.
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