Bruna Araujo David

Abstract The liver, a key metabolic organ, has a central role in maintaining systemic homeostasis but is vulnerable to numerous diseases. Its metabolic functions are mainly carried out by hepatocytes; however, the liver also harbours diverse non-parenchymal cell populations, including immune cells. Among these, Kupffer cells, the resident macrophages of the liver, are critical modulators of liver function and immunity.

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Editor’s summary Newborns are particularly vulnerable to bloodstream bacterial infections that can lead to meningitis, but the mechanisms underlying this susceptibility are not fully understood. Using real-time intravital microscopy of neonatal mice, Araujo David et al. found that relocalization of Kupffer cells (KCs) from the liver parenchyma into sinusoids during the first week of life coincides with improved clearance of bloodstream bacteria.