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Articles by Bryan Ng
DDX6 induces immunosuppression in cancer by disrupting structural stability of endogenous double-stranded RNAs
Editor’s summary Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Editor’s summary Cytosolic double-stranded RNA (dsRNA) can activate innate immune pathways, but adenosine-to-inosine RNA editing mediated by adenosine deaminases acting on RNA 1 (ADAR1) destabilizes dsRNA and prevents immune activation. Ng et al.
Hong Kong: SEHK issues new guidance letter highlighting its expectations on independent investigations conducted by long suspended issuers
On 26 November 2024, The Stock Exchange of Hong Kong Limited (SEHK) issued a new guidance letter (GL120-241) (“Guidance Letter“) to inform the market of its expectations on investigations conducted by suspended issuers and the roles of the directors and the independent investigation committees (IIC).
Tau depletion in human neurons mitigates Aβ-driven toxicity - Molecular Psychiatry
Abstract Alzheimer’s disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological accumulation of extracellular plaques and intracellular neurofibrillary tangles that mainly consist of amyloid-β (Aβ) and hyperphosphorylated tau aggregates, respectively. Previous studies in mouse models with a targeted knock-out of the microtubule-associated protein tau (Mapt) gene demonstrated that Aβ-driven toxicity is tau-dependent.
Hong Kong: Court agrees with Listing Review Committee's decision on internal control failures
In brief This recent Court of First Instance judgment ([2023] HKCFI 2932) is another unsuccessful judicial review against the decision of the Listing Review Committee (LRC) of The Stock Exchange of Hong Kong Limited to impose disciplinary sanctions on two independent non-executive directors (INED) (“Applicants“) of a listed company (“ListCo“). These applications remain to be an uphill battle.
Global Compliance News
In a series of webinars around the world, join our practitioners to uncover what is driving the future of disputes in Asia Pacific, Europe and the Americas through a global lens and gather key insights from battle-tested litigators on managing complex and multijurisdictional disputes, strengthening your organization’s litigation preparedness, and staying abreast of the emerging trends and challenges shaping the disputes landscape in the medium-to-long term.
Hong Kong: Court agrees with Listing Review Committee's decision on internal control failures
In brief This recent Court of First Instance judgment ([2023] HKCFI 2932) is another unsuccessful judicial review against the decision of the Listing Review Committee (LRC) of The Stock Exchange of Hong Kong Limited to impose disciplinary sanctions on two independent non-executive directors (INED) ("Applicants") of a listed company ("ListCo"). These applications remain to be an uphill battle.
Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson's GBA-N370S mutation
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15-year-old boy taken to hospital after being beaten up by a group of teens at fitness corner in Serangoon
SINGAPORE — A 15-year-old boy was taken to hospital after being beaten up by a group of teenagers at a fitness corner in Serangoon. In a statement on Thursday (Jan 26), the police said they received a call for assistance at a fitness corner near Block 201 Serangoon Central around 4.15pm on Jan 15. Eight teenagers aged between 11 and 14 are assisting with investigations, said the police, adding that the incident was being considered as a case of rioting.
The Rising Importance Of Soft Skills In Driving Productivity - Forbes India
Soft skills – the behavioural and social traits that enable individuals to work harmoniously with one another – are not just nice to have, they’re essential for the growth of a nation. In France, 60 percent of employers consider soft skills, such as the ability to organise, adapt and work in teams, to be more important than technical competencies. However, France is far behind other developed economies when it comes to its stock of soft skills.
‘We’ll still be family in afterlife’: Loved ones mourn, rescuers stunned by finds after Genting Highlands landslide
BATANG KALI — A man hugging his pet dog. A six-year-old girl in pink pyjamas. An entire family of four sleeping in a tent. They were among 30 people whose lives came to a rude, tragic halt in the early hours of Dec 16 morning at Father’s Organic Farm in Batang Kali, Selangor. Published December 23, 2022 Updated December 23, 2022 BATANG KALI — A man hugging his pet dog. An entire family of four sleeping in a tent. A six-year-old girl wearing pink pyjamas.
FairPrice places purchase limits on Panadol packs, manufacturer “producing record quantities” amid increased demand for over-the-counter flu medicine
SINGAPORE — Supermarket chain Fairprice has imposed purchase limits on the number of Panadol packs each customer can buy, while Panadol manufacturer Haleon says it is producing "record quantities" of the medicine, amid increased demand for over-the-counter fever, cold and flu related medicines in the past week.
HSA issues warning on cream for skin rashes after 4-year-old child ends up in hospital
SINGAPORE — A four-year-old child was taken to hospital after using a skin product supposed to treat rashes, the Health Sciences Authority (HSA) said on Thursday (Dec 22). Warning against its use, HSA said that the cream — known as Tao Ju Hui Yi Mei Li Shang Kou Hu Li Ruan Gao (淘聚汇益美丽伤口护理软膏) — had caused the child to suffer "serious adverse effects".
32-year-old woman arrested for allegedly splashing liquid thought to be alcohol at police at Sentosa ZoukOut event
SINGAPORE — A 32-year-old woman was arrested on Dec 7 after she allegedly splashed police officers with an unknown liquid believed to be alcohol during a ZoukOut event at Siloso Beach Sentosa on Dec 4. The officers were assisting in the evacuation of party goers after being alerted to a VIP stage that had sunk at the Siloso Beach event around 2.20am on Dec 4, said the police in a release on Thursday (Dec 22).
Police report lodged over boy allegedly throwing cat off 22nd floor of HDB block; incident caught on video
SINGAPORE — The police on Friday (Dec 16) confirmed that a report has been lodged over an incident caught on video where a boy allegedly threw a cat from the 22nd storey of a Housing and Development Board (HDB) block in Boon Lay. The cat is understood to have died of its injuries. The first video of closed-circuit television (CCTV) foootage of the incident was posted online on Thursday. It is time-stamped 1.35pm on Dec 14. The video has since been shared on multiple platforms.
43-year-old man arrested for suspected drink driving after car crashed into Geylang shop, 1 person taken to hospital
SINGAPORE — A 43-year-old man was arrested after the car he was driving crashed into a shop front along Geylang Road early on Wednesday (Dec 14), resulting in a shop assistant having to be taken to the hospital. In a statement on Wednesday, the Singapore Civil Defence Force (SCDF) said it was alerted to a road traffic accident near 345 Geylang Road at around 1.05am earlier that day.
Police warn against scammers posing as 'customers', targeting F&B businesses with fake reservations, orders
SINGAPORE — The police on Tuesday (Dec 13) called for businesses and members of the public to remain vigilant against fake restaurant reservation scams amid the festive season. The scam involves fake customers who call food and beverage (F&B) operators, such as restaurants, to reserve numerous tables and ask for expensive off-menu items, such as expensive wine or seafood.
One jailed, several others fined for role in fatal workplace accidents
SINGAPORE — A lorry driver has been sentenced to five months' jail for his actions which led to the death of a co-worker. The owner of his company, Ban Keong Transport, has also been charged. The case was among four fatal workplace accidents where the perpetrators were sentenced in November. All four cases involved instances where "shortcuts were taken and there was a lack of proper safe work procedures and risk assessments", the Ministry of Manpower (MOM) said in a statement on Monday (Dec 5).
National Care Hotline to cease from Dec 31, callers to be redirected to alternative helplines
SINGAPORE — The National Care Hotline will cease operations from 8pm on Dec 31, due to a decrease in the volume of calls received, said the Ministry of Social and Family Development (MSF) in a press release on Friday (Dec 2). “With the easing of safe management measures and the transition to living with Covid-19, the National Care Hotline observed an 85 per cent decrease in number of calls received in October 2022, compared to May 2020,” MSF said.
Police investigating 32-year-old woman for staging solo protest outside Chinese embassy in Singapore
SINGAPORE — A 32-year-old Singaporean woman is being investigated by the police for allegedly taking part in a public assembly outside the Chinese embassy without a permit on Monday (Nov 28). In a release on Tuesday, the police said they were alerted to an incident of a woman allegedly staging a protest "pertaining to issues in China" at around 12.55pm. “We directed the woman to stop her protest and she complied,” said the police.
2 more two workplace fatalities including 69-year-old worker who fell while cleaning windows at a condo
SINGAPORE — Two more fatal workplace accidents occurred last week including one incident involving a 69-year-old worker who fell while cleaning windows. In a release on Tuesday (Nov 29),the Ministry of Manpower (MOM) said that the two accidents took place on Friday and Saturday last week, bringing the total number of workplace fatalities in 2022 to 42. The accident involving the 69-year-old happened on Nov 26 around 6pm.
GST hike reflects PAP's responsibility in caring for present and future generations; WP should provide 'workable' alternatives in even 50 years: Chee Hong Tat
SINGAPORE — The government’s move to raise the Goods and Services Tax (GST) reflects People’s Action Party's (PAP) "moral and social responsibility" of caring for Singapore's population today, without taking away from future generations,said Senior Minister of State for Finance and Transport Chee Hong Tat on Tuesday (Nov 22). Ili Nadhirah Mansor/TODAY Follow us on Instagram and Tiktok, and join our Telegram channel for the latest updates.
Litterbugs made to clean up city areas under corrective work order, NEA says move will 'further drive home' the message
SINGAPORE — Corrective work order sessions were introduced at city areas for the first time in November this year as the National Environment Agency (NEA) seeks to increase the public visibility of such sessions. The first two sessions were held in Chinatown and Tanjong Pagar areas on Nov 15 and Nov 17, said NEA in a release on Friday (Nov 18).
Former Hyflux CEO Olivia Lum, ex-CFO and 4 independent directors charged with disclosure offences relating to Tuaspring project
SINGAPORE — Former Hyflux chief executive officer Olivia Lum Ooi Lin was charged on Thursday (Nov 17) for disclosure-related offences and her failure in ensuring Hyflux’s compliance with accounting standards. The company’s former chief financial officer Cho Wee Peng, and four independent directors of Hyflux were also charged for similar offences, said the police, the Monetary Authority of Singapore and the Accounting and Corporate Regulatory Authority in a joint release.
6 Australian teens in S'pore for elite netball camp arrested for alleged shoplifting of Crocs, lingerie at Orchard Road
SINGAPORE — Six teenagers were arrested on Sunday (Nov 13) after allegedly shoplifting from stores at the Mandarin Gallery at Orchard Road. In a statement on Wednesday, the police said they were alerted to a case of theft at 333A Orchard Road at 4.04pm on Sunday and arrested six teenagers aged 14 to 16 in relation to the case. Investigations are ongoing, the police added.
Driver arrested for drug-related offences after crashing into police car; police officer taken to hospital
SINGAPORE — A 43-year-old male driver was arrested for driving under the influence of drugs and other suspected drug-related offences after crashing into a police car along Jalan Besar Road in the wee hours of Friday (Nov 11). A police officer was taken to the hospital as a result of the incident.
Woman, 52, who shouted 'kangaroo court' at Benjamin Glynn trial charged with using insulting words, disorderly behaviour in court
SINGAPORE — A 52-year-old woman was charged on Friday (Nov 11) for using insulting words towards a public servant and disorderly behaviour in a courtroom during a trial in August 2021. Lee Hui Yin, 52, was attending the trial of Benjamin Glynn, a 40-year-old Briton who broke Covid-19 regulations by not wearing a mask on an MRT train and outside the State Courts.
The rising importance of soft skills in driving productivity
by Maria Guadalupe and Bryan Ng, INSEAD The economy of the future requires a workforce with strong soft skills. Investing in these crucial skills can result in increased productivity. Soft skills – the behavioural and social traits that enable individuals to work harmoniously with one another – are not just nice to have, they’re essential for the growth of a nation.
3 persons taken to hospital after accident at carpark in Yishun
SINGAPORE — Three people were taken to hospital after an accident involving three vehicles and two pedestrians at a carpark in Yishun on Tuesday (Nov 1). In a statement on Wednesday, the Singapore Civil Defence Force (SCDF) said it was alerted to a road traffic accident at the carpark of Block 259 Yishun Street 22. The Singapore Police Force said in a separate statement that the accident involved two cars, one motorcycle and two pedestrians.
The Rising Importance of Soft Skills in Driving Productivity
Next, we assessed the returns to soft skills by estimating wage regressions in France. The results showed that a one standard deviation increase in soft skills is associated with a 4.2 percent increase in hourly wages, and a one standard deviation increase in numeracy skills is associated with a 4.4 percent increase. Put simply, the correlation between individual wages and soft skills is as high as the correlation between individual wages and numeracy skills.
Over 1,800 enforcement actions taken against more than 500 companies after MOM workplace safety inspections
SINGAPORE — Authorities conducted more than 750 inspections aimed at reducing workplace slips, trips between Aug 15 to Oct 17, which resulted in enforcement actions being taken against more than 500 companies, the Ministry of Manpower (MOM) in a Facebook post on Monday (Oct 31). In all, 1,828 enforcement actions were taken against 558 companies, MOM said. These included 12 Stop Work Orders and 232 composition fines amounting to S$499,150.
Richard Branson declines live TV debate on death penalty, says 'brave thing' for Shanmugam to do is to engage S'porean activists
SINGAPORE — British billionaire Richard Branson has declined the Singapore government's invitation for a live televised debate over its approach towards drugs and the death penalty, as he urged Home Affairs and Law Minister K Shanmugam to engage local activists instead.
2 persons taken to hospital after 9-vehicle chain collision at KPE tunnel
Published October 29, 2022 Updated October 29, 2022 Singapore roads accident/Facebook Two people were taken to hospital after a nine-vehicle chain collision in the Kallang-Paya Lebar Expressway (KPE) tunnel on Thursday (Oct 27) afternoon. The Singapore Civil Defence Force were alerted at around 4.45pm to the accident, which happened along KPE towards Tampines Expressway (TPE) after the Bartley Road East exit.
2 persons taken to hospital after 9-vehicle chain collision at KPE tunnel
SINGAPORE — Two people were taken to hospital after a nine-vehicle chain collision at the Kallang–Paya Lebar Expressway (KPE) tunnel on Thursday (Oct 27) afternoon. Singapore roads accident/Facebook Follow us on Instagram and Tiktok, and join our Telegram channel for the latest updates.
Video platform TikTok rolls out photo slideshow feature to rival Instagram’s photo carousel
SINGAPORE — Social media platform TikTok, best known for its short videos, has gradually rolled out a photo slideshow feature in recent weeks that could rival Instagram’s long-running photo carousel feature. The feature, called ‘photo mode’, is available in most regions globally including Singapore and allows TikTok users to share multiple still images in a single post, along with captions of up to 2,200 characters.
Producers of #LookAtMe not appealing IMDA decision barring film from being screened in S'pore
SINGAPORE — The producers of Singapore-made film #LookAtMe will not be appealing the Infocomm Media Development Authority’s (IMDA) decision to not classify the film, effectively barring it from being screened domestically. In a statement on Thursday (Oct 27), the producers said that while they disagree with the reasons for the ban, they had done a comprehensive assessment of the appeals process and decided against submitting an appeal.
60-year-old ambulance driver dies after crashing into tree along Sengkang East Road
SINGAPORE — A 60-year-old driver died after the ambulance he was driving crashed into a tree along Sengkang East Road on Thursday (Oct 20) morning. In a statement on Friday, the Singapore Civil Defence Force (SCDF) said they were alerted to a road traffic accident at the junction of Sengkang East Road and Sengkang East Avenue at around 8.20am on Thursday.
Former Mediacorp actor James Lye named global head of international banking at Standard Chartered
SINGAPORE — Former Mediacorp actor James Lye, most well-known in Singapore for his starring roles in local dramas Triple Nine and VR Man, has been named global head of international banking at Standard Chartered. The bank said in a statement on Thursday (Oct 20) that Mr Lye, who was previously at Citibank, will take up the newly created role on Nov 1 and be based in Singapore, where he will lead the group’s international banking team.
Tower Transit bus captain, 64, suspended after bus crashes through road divider at Ang Mo Kio
SINGAPORE — A 64-year-old bus captain has been suspended after the bus he was driving crashed through a road divider at Ang Mo Kio on Wednesday (Oct 12) morning. Responding to TODAY’s queries on Thursday, bus operator Tower Transit said the accident involved service 853. Nine passengers were on board when it happened. “No one was injured,” the operator added. "The bus captain has been suspended while an investigation is being conducted," it said.
Taxi driver, 69, arrested for closing window on traffic cop's arm and dragging him along the road
SINGAPORE — A 69-year-old taxi driver was arrested on Sunday (Oct 9) after he allegedly wound up his window on a traffic police officer's arm and drove off, dragging the officer along the road. The 34-year-old officer was patrolling around Holland Road, when he spotted the taxi driver purportedly using his mobile phone while driving. He signalled for the driver to stop, but the man ignored him and continued driving.
SBS Transit driver dies after crashing empty bus into tree near Hougang bus depot
SINGAPORE — A SBS Transit driver died in the wee hours of Sunday morning (Oct 9), after the empty bus he was driving crashed into a tree next to his destination in Hougang. In a statement on Monday, the police said they were alerted to an accident involving a bus along Defu Avenue 1 towards Hougang Avenue 3 at 2.47am. The Singapore Civil Defence Force (SCDF) said they found a person found trapped in the driver seat of a bus and extricated him.
6 people trapped in Jurong West lift with body for 50 minutes, Town Council says lift was overloaded
SINGAPORE —While carrying a body of a deceased relative to a wake on the first floor, six people were stuck in a lift at Jurong West for 50 minutes on Tuesday (Oct 4), until lift technicians and personnel from the Singapore Civil Defence Force (SCDF) were able rescue them. In response to media queries on Thursday, SCDF said they received a call for assistance at Block 760 Jurong West Street 74, a Housing and Development Board block, at around 2.05pm on Tuesday.
Construction firm Fusion Builders and director fined for safety lapses resulting in worker death
SINGAPORE — Construction firm Fusion Builders and its director, Ng Chin Sang, have been fined S$250,000 and S$60,000 respectively for workplace safety lapses that resulted in the death of a worker in 2017. In a statement on Thursday (Oct 6), the Ministry of Manpower (MOM) said the company and Ng, 72, were fined on Oct 4 after pleading guilty to offences under the Workplace Safety and Health Act for not taking reasonably practicable measures to ensure the safety and health of workers.
4 HDB precincts, including new Ulu Pandan estate, to be zoned as car-lite precincts with fewer parking lots
SINGAPORE — Six areas, including four new public housing estates, will be designated ascar-lite zones and will feature fewer parking lots than usual, the Housing and Development Board (HDB) and Land Transport Authority (LTA) in a joint release on Wednesday (Oct 5). The areas to be gazetted by LTA on Oct 31 are the housing estates of Ulu Pandan, Tengah, Mount Pleasant, Keppel Club in Greater Southern Waterfront, as well as Tanjong Rhu and Pearl’s Hill.
New bird park set to open in Mandai precinct in Q2 2023 featuring over 400 bird species
SINGAPORE — Singapore’s new bird park, Bird Paradise, will be home to 3,500 birds from more than 400 avian species and is set to open in the second quarter of 2023. The current bird park — Jurong Bird Park — is scheduled to close on Jan 3 next year, exactly 52 years after it opened in 1971.
Bus hits 74-year-old pedestrian in Sengkang, driver arrested for careless driving
SINGAPORE — A 68-year-old male bus driver has been arrested for careless driving after an accident at a traffic junction in Sengkang injured an elderly pedestrian, the police said on Friday (Sept 30). The authorities said they were alerted to an accident involving a bus and a 74-year-old pedestrian at the junction of Compassvale Road and Compassvale Drive at about 10.50pm on Thursday night.
S$200 fine for those caught smoking at public parks, beaches from Oct 1
SINGAPORE — Those caught smoking at public parks and gardens, recreational beaches, and water projects managed by national water agency PUB may face a composition fine of S$200 from Oct 1. The enforcement action comes after a three-month advisory period from July 1, during which more than 1,200 warnings were issued, said the National Environment Agency (NEA), the National Parks Board (NParks), PUB, and Sentosa Development Corporation (SDC) in a joint news release on Thursday (Sept 29).
Deputy Attorney-General Hri Kumar Nair to be appointed High Court judge
SINGAPORE — Deputy Attorney-General Hri Kumar Nair will assume the role of High Court judge on Jan 2, said the Prime Minister’s Office (PMO) in a statement on Monday (Sept 26), which listed out several other new appointments. Mr Nair has been Deputy Attorney-General since March 1, 2017 and has more than 25 years of experience as a litigator.
Police investigating complaints of thumbtacks found scattered across pavements in Yishun
SINGAPORE — The police are investigating what appears to be a series of incidents where thumbtacks have been found scattered across pavements in Yishun. In response to TODAY’s queries on Wednesday (Sept 21), the police said that “reports were lodged and investigations are ongoing”. Videos and pictures circulating online about the incident show members of the public picking up thumbtacks from pavements and a thumbtack lodged in the wheel of what appears to be a food delivery rider's bicycle.
Police officer, 29, found with gunshot wound at Bayfront Avenue dies; no foul play suspected
SINGAPORE — A 29-year-old police officer was found with a gunshot wound along 1 Bayfront Avenue and was subsequently pronounced dead on Monday (Sept 19). In a statement on Monday, the police said the officer was from Central Police Division and a firearm was found at the scene and seized. “Based on preliminary investigations, police do not suspect foul play and investigations are ongoing,” they added.
Police officer, 29, found with gunshot wound on Bayfront Avenue believed to have shot air twice before shooting himself
SINGAPORE — A 29-year-old police officer was found with a gunshot wound at 1 Bayfront Avenue and was later pronounced dead on Monday (Sept 19). He was believed to have shot into the air twice before firing a third shot at himself. On Monday, the police said that the officer was from the Central Police Division and a service pistol was found at the scene and seized.
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