Bryhan Mendez on Muck Rack

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Articles

Renalase inhibition regulates β cell metabolism to defend against acute and chronic stress

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By Tara MacDonald, Birgitta Ryback, Siying Wei, Bryhan Mendez
| biorxiv.org
Abstract Renalase (Rnls), annotated as an oxidase enzyme, is a GWAS gene associated with Type 1 Diabetes (T1D) risk. We previously discovered that Rnls inhibition delays diabetes onset in mouse models of T1D in vivo, and protects pancreatic β cells against autoimmune killing, ER and oxidative stress in vitro. The molecular biochemistry and functions of Rnls are entirely uncharted.
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