Siying Wei
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Severity and Associated Factors of Alarm Fatigue Among Intensive Care Unit Nurses: A Systematic Review and Meta-Analysis
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description nicc70666-sup-0001-Tables.docxWord 2007 document , 113.6 KB Table S1: Detailed search strategies. Table S2: AHRQ assessment of literature quality.
Loss of function of ALDH3B2 transdifferentiates human pancreatic duct cells into β-like cells
Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Abstract Replenishment of pancreatic β cells is key to a cure for diabetes. β cell regeneration is achieved predominantly by self-replication, especially in rodents, but it was also shown that pancreatic duct cells can transdifferentiate into β cells.
Renalase inhibition regulates β cell metabolism to defend against acute and chronic stress
Abstract Renalase (Rnls), annotated as an oxidase enzyme, is a GWAS gene associated with Type 1 Diabetes (T1D) risk. We previously discovered that Rnls inhibition delays diabetes onset in mouse models of T1D in vivo, and protects pancreatic β cells against autoimmune killing, ER and oxidative stress in vitro. The molecular biochemistry and functions of Rnls are entirely uncharted.
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