Bülent Arman Aksoy on Muck Rack

Bülent Arman Aksoy

As seen in: Nature, Cell Press
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Articles

The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner.

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By Connor Dwyer, Hannah M. Knochelmann, Aubrey S. Smith, Bülent Arman Aksoy
| biorxiv.org
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Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis

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By Jeffrey Vedanayagam, Bülent Arman Aksoy, Anders Jacobsen Skanderup, Chris Sander
| Nature Verified
Abstract Somatic mutations in the RNase IIIb domain of DICER1 arise in cancer and disrupt the cleavage of 5' pre-miRNA arms. Here, we characterize an unstudied, recurrent, mutation (S1344L) in the DICER1 RNase IIIa domain in tumors from The Cancer Genome Atlas (TCGA) project and MSK-IMPACT profiling. RNase IIIa/b hotspots are absent from most cancers, but are notably enriched in uterine cancers.
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A Landscape of Metabolic Variation across Tumor Types

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By Ed Reznik, Eric Liu, Augustin Luna, Bülent Arman Aksoy
| Cell Press Verified
Analysis of Metabolic Variation in Tumors and Normal Tissue In spite of the diversity of genetic alterations across cancers, it is possible that the development of cancer may place common demands on cellular metabolism, irrespective of the tissue of origin. In this study, we offer a glimpse into the common patterns and distinguishing features of metabolic reprogramming across cancers.
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