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Byarugaba D.K on Muck Rack

Byarugaba D.K

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Articles

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus

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By Samantha Zepeda, Ashley Taylor, Joel D. Quispe, Byarugaba D.K
| Cell Host & Microbe Verified
Highlights • PRD-0038 clade 3 sarbecovirus spike has a broad ACE2 receptor usage • RBD mutations expand tropism to additional Rhinolophus ACE2s and to human ACE2 • Cryo-EM blueprints explain receptor tropism and spike antigenicity • Identification of PRD-0038 cross-neutralizing antibodies for pandemic preparedness Summary Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins...
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