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Byungji Kim on Muck Rack

Byungji Kim

As seen in: Nature, The BMJ, BioRxiv, eLife, JoVE- Journal of Visualized Experiments, World Today News, Newsdirectory3
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Articles

Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression

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By Byungji Kim, Malte Roerden, Andrea Castro, Yufei Cui
| The BMJ Verified
Discussion ITH and subclonal NeoAg expression have emerged as key determinants of potent antitumor immunity and predict response to ICB in patients with cancer.13 16 The underlying mechanisms leading to reduced antitumor immunity in tumors with heterogenous NeoAg expression however remained poorly understood. We here uncover how NeoAg architectures affect T-cell priming by cDC1 in the tdLN to suppress NeoAg immunogenicity, thus enabling immune escape.
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PPARγ downregulation in colonic CD8+ T cells results in epithelial barrier disruption in people with HIV on antiretroviral therapy

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By Byungji Kim, Leah Froehle, Upasana Das Adhikari, Alexandra N Pipkin
| BioRxiv
Abstract A hallmark of HIV infection is disruption of intestinal barrier integrity that persists in people with HIV (PWH) despite treatment with antiretroviral therapy (ART). This disruption is central to HIV disease progression, yet the causes remain incompletely understood. We report a novel mechanism by which immunometabolic defects in colon resident CD8+ T cells in PWH lead to intestinal epithelial apoptosis and disruption of intestinal barrier integrity.
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Rapid protein evolution by few-shot learning with a protein language model

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By Byungji Kim, Kaiyi Jiang, Matteo Di Bernardo, Zhaoqing Yan
| BioRxiv
Abstract Directed evolution of proteins is critical for applications in basic biological research, therapeutics, diagnostics, and sustainability. However, directed evolution methods are labor intensive, cannot efficiently optimize over multiple protein properties, and are often trapped by local maxima.
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