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Abstract The intestinal epithelium plays a critical role in health and disease, yet the impact of microenvironmental cues in diseased contexts, such as inflammatory bowel disease (IBD), remains poorly defined. To address this gap, we first benchmarked human colonic organoid injury models against IBD tissue and established a disease-relevant model of inflammation using inflammatory cytokines.
Short articleVolume 32, Issue 4p640-651.e9Open access Affiliations & Notes 1Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, United States of America 2Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, United States of America 3Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America 4Department of...
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