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Cailing Yin on Muck Rack

Cailing Yin

As seen in: Nature
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Articles

Functional characterization of viral transcriptional regulators reveals extensive rewiring of host pathways

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By Jaice T. Rottenberg, Xing Liu, Luis F. Soto-Ugaldi, James E. Corban, Phillip J Dexheimer, Matthew R. Hass, Clarissa Santoso, Ryan Lane, Sakshi Shah, Kerstin Spirohn-Fitzgerald, Shubham Khetan, Cheng-Che Lee, Zhaorong Li, Yunwei Lu, S. Stephen Yi, Nidhi Sahni, Martha L. Bulyk, Michael Calderwood, Leah C. Kottyan, Matthew T Weirauch, Marc Vidal, Srivatsan Raman, Juan Bass, Mohamed Y. ElSadec, Anna Lagani, Cailing Yin, Berkay Engin, George Muñoz-Esquivel, Lucia Martinez-Cuesta, Philipp Trollmann
| Nature Verified
Abstract Viral transcriptional regulators (vTRs) reprogram host gene regulatory networks to promote replication, persistence, and immune evasion. Despite the identification of hundreds of vTRs in human viruses, how they rewire host pathways remains unclear. Here, we systematically profiled 95 vTRs from diverse human viruses across multiple functional assays.
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