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Matthew T Weirauch on Muck Rack

Matthew T Weirauch

As seen in: Nature, Bustle, Genome Biology, BioRxiv, Cell Press, Cell Reports, Inverse, eLife, The Journal of Allergy & Clinical Immunology
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Articles

‘Mono’ Virus Found to Broadly Influence Human Genes

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By Leah C. Kottyan, Matthew T Weirauch
| cincinnatichildrens.org
Epstein-Barr virus, or EBV, is best known as the cause of infectious mononucleosis (often referred to as “mono”). After infection, the virus can persist for life in immune cells, especially B cells. EBV also has also been associated with several cancers and immune-mediated diseases. However, a key question has remained: how much, and through what means, does a virus that lives inside human cells alter the activity of the human genome?
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Systematic discovery of pathogen effector functions across human pathogens and pathways

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By Tomas Pachano, He Leng, Guillaume Dugied, Travis Tribble, Vincent LOUBIERE, Yeojin Lee, Felix Rauh, Victor A Manon, Kevin Yuan, Jocelyn Nurtanto, Alexander Schleiffer, Veronika Young, Benjamin Weller Verified, Eleanor Lyons, Matthew R. Hass, Leah C. Kottyan, Matthew T Weirauch, Juan Bass, Hayley J. Newton, Alexander W Ensminger, Pascal Falter-Braun, Jue Chen, Daniel Schramek, Alexander Stark, Mikko Taipale
| Cell Press Verified
We next performed four additional screens representing pathways that are broadly relevant: p53 signaling, STING signaling, apoptosis, and major histocompatibility complex class I (MHC-I) antigen presentation. The p53 tumor suppressor regulates cell cycle progression, apoptosis, and the DNA damage response and is a frequent target of viral oncogenes.66 The cGAS-STING pathway acts as the major innate immune sensor for cytoplasmic double-stranded DNA (dsDNA).
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Cross-platform motif discovery and benchmarking to explore binding specificities of poorly studied human transcription factors - Communications Biology

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By Ilya Vorontsov, Ivan Kozin, Sergey A. Abramov, Arttu Jolma, Giovanna Ambrosini, Katerina Faltejskova, Pavel Kravchenko, Judith F. Kribelbauer-Swietek, Kaitlin U Laverty, Vladimir Nozdrin, Dmitry Penzar, Arsenii Zinkevich, Matthew T Weirauch, Philipp Bucher, Bart Deplancke, Oriol Fornes, Jan Grau, Ivo Grosse, Vsevolod J. Makeev, Timothy Hughes, Antoni J. Gralak, Marie-Luise Plescher
| Nature Verified
Abstract A sequence motif representing the DNA-binding specificity of a transcription factor (TF) is commonly modelled with a positional weight matrix (PWM). Focusing on understudied human TFs, we processed results of 4,237 experiments for 394 TFs, assayed using five different experimental platforms.
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