Caitlyn W Barrett

By Yale Rosen from USA on Wikimedia Commons Sarcoidosis is a rare but serious inflammatory disease….It disproportionately affects Black Americans, particularly Black women, who experience some of the highest rates of the disease.

This paper is only available as a PDF. To read, Please Download here. Abstract Background and Aims Patients with inflammatory bowel disease (IBD) demonstrate nutritional selenium deficiencies and are at greater risk for colon cancer. Previously, we determined that global reduction of the secreted antioxidant selenium-containing protein, Selenoprotein P (SELENOP), substantially increased tumor development in an experimental colitis-associated cancer (CAC) model.

Objective Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated cancer (CAC), its cellular function and its relevance to patients with IBD.