Caiwen Mao on Muck Rack

Caiwen Mao

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Articles

Structural insights into the activation of TMEM175 by small molecule

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By Xuewu Zhu, Meixuan Ping, Heng Liu, Ting Yu, Zhongwen Jiang, Zhenhua Liu, Chanjing Li, Xinjiao Hou, Qinyu Chu, Shuyao Li, Caiwen Mao, Ting Luo, Chunlan Kang, Feng Wang, Chuanyan Yang, Meiqin Tang, Zhidong Jiang, Zhaobing Gao, Hong liu, H. Xu, Beisha Tang, Wanchao Yin, Yu Zhou, Ping Li
| Cell Press Verified
Keywords TMEM175 agonist binding site Parkinson’s disease lysosome Introduction Parkinson’s disease (PD), the second most common neurodegenerative disorder, with approximately 6.1 million people worldwide,1,2,3 appears to result from the widespread accumulation of aberrant α-synuclein, the neuropathological hallmark of PD,4,5 but the underlying mechanism is largely unknown.6,7 PD symptoms are most commonly treated with symptomatic treatments, such as dopaminergic medications, that have...
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