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Articles by Caleb Webber
GWAS of extended prescription analgesic use identifies genetic loci in chronic pain
Abstract Pain-related conditions are the leading cause of disability worldwide. Existing GWAS for chronic pain have mainly focused on individual pain-related disorders, which may not optimally capture the phenotype. Here, we define chronic pain based on prescription analgesic use ( ≥ 90 days) in two large biobanks (UK Biobank and FinnGen).
Modeling common Alzheimer’s disease with high and low polygenic risk in human iPSC: A large-scale research resource
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Keywords iPSC stem cells Alzheimer’s disease polygenic risk PRS IPMAR complement EOAD LOAD Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. At the core of Alzheimer’s pathology is the accumulation of β-amyloid plaques and neurofibrillary tangles composed of hyperphosphorylated tau in the brain and the degeneration and death of neurons (Serrano-Pozo et al., 2011).
By EMILY MAGUIRE, Sarah Ellwood, Rachel O’Donoghue, Bethany Shaw, Atahualpa Castillo Morales, Samuel B.K. Keat, Alexandra T. Evans, Rachel Marshall, Laura Brown Verified, Ganna Leonenko, Nicholas Allen, Valentina Escott-Price, Caleb Webber, Philip Taylor, Rebecca Sims, Sally A. Cowley, Julie Williams, Jincy Winston, Lauren Luckcuck, Elisa Salis, Nicola Denning, Sarah M. Carpanini, Hazel Hall-Roberts
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Stem Cell Reports
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A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease | Nature Communications
Abstract Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer’s disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD and non-diseased control brains to characterise pathological transcriptional signatures responsible for this. We show that endothelial cells (EC) are enriched for expression of genes associated with susceptibility to AD.
Cells | Free Full-Text | Single-Cell Transcriptomics and In Vitro Lineage Tracing Reveals Differential Susceptibility of Human iPSC-Derived Midbrain Dopaminergic Neurons in a Cellular Model of Parkinson’s Disease
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Single-Cell Transcriptomics Reveals Conserved Regulatory Networks in Human and Mouse Interneuron Development
Open AccessArticle by 1,†, 2,†, 1,3, 2 and 1,3,* 1 Neuroscience and Mental Health Research Institute, School of Medicine, Cardiff University, Cardiff CF24 4HQ, UK 2 UK Dementia Research Institute Cardiff, Cardiff University, Cardiff CF24 4HQ, UK 3 Division of Neuroscience, School of Bioscience, Cardiff University, Cardiff CF10 3AX, UK * Author to whom correspondence should be addressed. † These authors contributed equally to this work. Int. J. Mol. Sci.
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