Callum J Dickson on Muck Rack

Callum J Dickson

As seen in: ACS Publications, Cell Press, Chemistry World
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Articles

Promise and Challenge of β-Lactone Electrophiles to Target Aspartate 12 of Mutant KRASG12D

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By Balázs Budai, Callum J Dickson, Kim Beyer, Andrea Vaupel
| ACS Publications
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Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels

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By Swastik Phulera, Novartis Biomedical Research, Callum J Dickson, Christopher J. Schwalen
| Cell Press Verified
Ahern C.A. Payandeh J. Bosmans F. Chanda B. The hitchhiker’s guide to the voltage-gated sodium channel galaxy. J. Gen. Physiol. 2016; 147: 1-24https://doi.org/10.1085/jgp.201511492 Han C. Huang J. Waxman S.G. Sodium channel Nav1.8: Emerging links to human disease. Neurology. 2016; 86: 473-483https://doi.org/10.1212/WNL.0000000000002333 Cox J.J. Reimann F. Nicholas A.K. Thornton G. Roberts E. Springell K. Karbani G. Jafri H. Mannan J. Raashid Y. et al.
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Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels

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By Swastik Phulera, Callum J Dickson, Christopher J. Schwalen, Maryam Khoshouei
| biorxiv.org
Abstract Voltage-gated sodium (Nav) channels sense membrane potential and drive cellular electrical activity. Numerous protein toxins have been identified that modulate Nav gating, and structures of Nav channels in complex with these toxins helped elucidate the molecular mechanisms of voltage-dependent channel gating. The deathstalker scorpion α-toxin LqhαIT exerts a strong action potential prolonging effect on Nav channels.
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