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Canxue Zhang on Muck Rack

Canxue Zhang

As seen in: Nature
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Articles

PSMD11 promotes hepatocellular carcinoma progression by reprogramming lipid metabolism via SREBP1/2 and PPAR-γ

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By Zhihong Huang, Chi Zhang, Yuqi Liu, Chao Ge, Zhujun Wei, Li Zhang, Yue Yang, Wei Tian, Hua Tian, Canxue Zhang
| Nature Verified
Abstract Dysregulation of the ubiquitin-proteasome system (UPS) plays a pivotal role in tumor progression. PSMD11, a non-ATPase regulatory subunit of the 26S proteasome, has been implicated as an oncogenic factor in several cancer types; however, its precise biological function and molecular mechanisms in hepatocellular carcinoma (HCC) remain incompletely understood. In this study, we demonstrated that PSMD11 was markedly upregulated in HCC tissues and correlated with poor patient prognosis.
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