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Caralyn Gonzales on Muck Rack

Caralyn Gonzales

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Articles

Directionality of transcriptional regulatory elements

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By YOU WEI CHEN, Sagar Shah, Alden K Leung, Mauricio I. Paramo, Kelly Cochran, Austin Wang, Anshul Kundaje, Andrew Clark, John T. Lis, Haiyuan Yu, Caralyn Gonzales
| Nature Verified
Abstract Divergent transcription is a critical marker of active transcriptional regulatory elements (TREs), including enhancers and promoters, in mammals. However, distal elements with unidirectional transcriptional patterns are often overlooked, leaving their identity and function poorly understood. Here, we perform a systematic comparison between divergent and unidirectional elements, revealing their distinct architectural and functional features.
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