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Carea Mullin on Muck Rack

Carea Mullin

As seen in: The Journal of Clinical Investigation
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Articles

The hematopoietic stem cell MYB enhancer is essential for and recurrently amplified during T cell leukemogenesis

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By Carea Mullin, Karena Lin, Elizabeth Y. Choe, Cher Sha
| The Journal of Clinical Investigation
Abstract There is an urgent need to find targeted agents for T cell acute lymphoblastic leukemia (T-ALL). NOTCH1 is the most frequently mutated oncogene in T-ALL, but clinical trials showed that pan-Notch inhibitors caused dose-limiting toxicities. Thus, we shifted our focus to ETS1, which is one of the transcription factors that most frequently co-bind Notch-occupied regulatory elements in the T-ALL context.
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