The phase 2 TUXEDO-3 trial identifies the HER3-targeting antibody–drug conjugate patritumab deruxtecan as a promising new therapeutic option for patients with leptomeningeal metastasis from solid tumors. Enjoying our latest content? Login or create an account to continue Access the most recent journalism from Nature's award-winning team Explore the latest features & opinion covering groundbreaking research or References Ozair, A. et al. Nat. Rev. Clin. Oncol. 22, 134–154 (2025).