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We have recently discovered that the ZZ zinc finger domain represents a novel small ubiquitin-like modifier (SUMO) binding motif. In this study we identify the binding epitopes in the ZZ domain of CBP (CREB-binding protein) and SUMO1 using NMR spectroscopy. The binding site on SUMO1 represents a unique epitope for SUMO interaction spatially opposite to that observed for canonical SUMO interaction motifs (SIMs).
Author contributions: CD expressed and purified the proteins, and conducted the NMR experiments including analysis of results. MA contributed with experimental design and interpretation of the CPMG relaxation dispersion experiments. SBJ and NL provided biological data assessments and expertise. WS and MW performed the ITC experiments. MW designed the study, served as the project supervisor, and wrote the paper with input from all other authors.
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