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Carl-Fredrik Flach on Muck Rack

Carl-Fredrik Flach

As seen in: Nature, ScienceDirect, MDPI, medRxiv
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Articles

Antibiotic resistance gene analyses in microbial communities: challenges and opportunities

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By D. G. Joakim Larsson, Carl-Fredrik Flach, Erik Kristiansson
| Nature Verified
Culture-independent antibiotic resistance gene analyses enable broad explorations of microbial communities but often fail to link such genes to bacterial hosts and genetic contexts. This makes assessing prevalence of resistant pathogens and likelihood of further transmission or resistance evolution uncertain. References Larsson, D. G. J. & Flach, C.-F. Antibiotic resistance in the environment. Nat. Rev. Microbiol. 20, 257–269 (2022). Google Scholar Ouyang, B. et al.
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Antibiotic resistance selection and deselection in municipal wastewater from 47 countries - Nature Communications

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By Jerker Fick, Roman Grabic, Mats Tysklind, Hannah-Marie Martiny, Carl-Fredrik Flach, Frank M. Aarestrup, Zhuofeng Yu, Noel Waters, Mutshiene Deogratias Ekwanzala
| Nature Verified
Abstract Wastewaters are plausible arenas for antibiotic resistance evolution and transmission, yet selection for resistance by municipal wastewater has rarely been empirically demonstrated. Here, we experimentally investigate the potential of untreated municipal wastewater from 47 countries to select for antibiotic resistance and explore possible drivers.
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Evaluating Wastewater Surveillance for Estimating Pharmaceutical Use

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By Jerker Fick, Carl-Fredrik Flach, Erik Kristiansson, Gilbert Odindo Osena
| medRxiv
The authors have declared no competing interest. This study was funded by SciLifeLab & Wallenberg Data Driven Life Science Program (grant: KAW 2020.0239). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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