Carl Gay

Key Words lung cancer local consolidative therapy pulmonary resection targeted therapy metastatic stage IV A subset of patients with metastatic lung cancer may achieve improvement in outcomes with local therapy including surgery, with nuanced consideration of both patient selection and operative timing. See Commentary on page 882.

Highlights • Small cell lung cancer subtypes can be assessed using RNA-seq and predictive models • Small cell lung cancer subtypes have subtype-specific DNA methylation profiles • DNA methylation allows subtyping from both tissue and liquid biopsies • Liquid biopsies offer a less invasive alternative for patient subtype assignment Summary Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, but implementing subtyping in the clinic has...