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Carl-Henrik Heldin on Muck Rack

Carl-Henrik Heldin

As seen in: Nature, MDPI, The Journal of Biological Chemistry
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Articles

Targeting oncogenic TβRI signaling inhibits androgen-independent prostate cancer growth and metastasis

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By Alexej Schmidt, Yabing Mu, Guangxiang Zang, Jie Song, Olena Rakhimova, Madelene Ericsson, Karthik Aripaka, Sofia Halin Bergström, Wei Yuan, Denisa Bogdan, Aaron Zhang, Jon C. Welti, Anders Bergh, Johann De Bono, Carl-Henrik Heldin, Maréne Landström, Per Flodbring Larsson, Vishnupriya Gajavilli, Junting Tao
| Nature Verified
Abstract Metastatic castration-resistant prostate cancer (mCRPC) remains the primary cause of prostate cancer-related mortality. Despite the availability of treatments, the molecular mechanisms underlying tumor invasion and metastasis are not fully understood, highlighting the need for novel therapeutic strategies.
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TGFβ signaling promotes cell cycle progression and resistance to the CDK4/6 inhibitor palbociclib through SOX4 transcriptional modulation in breast cancer cells | Cell Death & Disease

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By Mohamad Ali, Sarah K. Gallant, Yu Zuo Bai, Keiji Miyazawa, Carl-Henrik Heldin, Chrysoula Tsirigoti
| Nature Verified
Abstract Cancer signaling encompasses a wide array of entangled molecular cascades that promote oncogenic progression and counteract the effect of tumor suppressors. Transforming growth factor β (TGFβ) induces complex and stage-dependent effects throughout tumor progression. During pre-malignant hyperplastic growth, TGFβ restricts cell proliferation and inflammation, while on the other hand, TGFβ promotes migration and distal metastasis of cancer cells.
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The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma - Cell Death & Differentiation

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By Mohamad Ali, Paula Martín-Rubio, Kohei Miyazono, Laia Caja, Carl-Henrik Heldin, Fredrik J. Swartling
| Nature Verified
Abstract Oncogenic events perturb cerebellar development leading to medulloblastoma, a common childhood brain malignancy. Molecular analyses classify medulloblastoma into the WNT, SHH, Group 3 and Group 4 subgroups. Bone morphogenetic protein (BMP) pathways control cerebellar development and have been linked to the progression of medulloblastoma disease, with major remaining gaps in their mechanistic and clinically-relevant roles.
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